He completed his (Uma Nyinpa)- middle school of the Madhyamika School of Buddhism at the age of 12 at Drepung Monastery in Lhasa and. He was 4 years junior to Tarab Rinpoche and they stayed close friend throughout life.
Rinpoche fled to exile in the year 1959. And on 4th February 1960 he received the Bhiksu ordination from His Holiness the Dalai Lama. He served as principal of Shimla Tibetan School in 1963. From 1965 to 1970 he was Principal of Dalhousie Tibetan School. He received his Lharampa Degree in the year 1968 and Ngagrimpa Degree in 1969. From 1971 to 1988 he was the Principal of then Central Institute of Higher Tibetan Studies (CIHTS, Varanasi). From 1988 to 2001 he worked as the Director CIHTS and was awarded the professorship by Banaras Hindu University for his deep knowledge in numerous eastern studies. From 1999 to 2000, Rinpoche was the president of the Association of Indian Universities (AIU), a strong academic group of more than 250 Vice-Chancellors of Indian Universities.
In 2013 Samdhong Rinpoche has been named chancellor of the Sanchi University of Buddhist-Indic Studies in Madhya Pradesh.
He is an eminent and distinguished scholar, teacher and philosopher, and a life-long campaigner of non-violence or peaceful resistance, and he is a Board member of Tarab Ling Association.